General Oncology to Present Preliminary Phase 1 Results from SHARON Trial in Patients with BRCA/PALB2-mutated Pancreatic and Breast Cancer at ESMO 2025

BOSTON, Oct. 13, 2025 (GLOBE NEWSWIRE) -- General Oncology, Inc. (“General Oncology” or the “Company”), a clinical-stage biopharmaceutical company dedicated to pioneering first-in-class medicines for metastatic cancers, today announced that it will deliver a poster presentation featuring preliminary results from its ongoing Phase 1 SHARON trial (NCT04150042) evaluating GO-4: the Company’s patented Advanced Redox Modulation regimen consisting of melphalan, BCNU, hydroxocobalamin, ascorbic acid, and autologous stem cell infusion in patients with advanced pancreatic ductal adenocarcinoma or breast cancer harboring an inherited BRCA/PALB2 mutation at the upcoming European Society of Medical Oncology (ESMO) Congress 2025, taking place October 17-21 in Berlin, Germany.

Poster Presentation Details:

Title: The SHARON Trial: Melphalan, BCNU, Hydroxocobalamin, Ascorbic Acid, and Stem Cells for Pancreatic and Breast Cancer and an Inherited BRCA/PALB2 Mutation
Abstract Number: 2228P
Presenter: Kenneth H. Yu, M.D., Memorial Sloan Kettering Cancer Center, Principal Investigator
Date and Time: Sunday, October 19 at 12:00–12:45 CEST
Location: Poster Area, Hall 25

About the SHARON Trial
The SHARON trial is a Phase 1 study designed to evaluate the safety, feasibility, and preliminary efficacy of GO-4, the Company’s patented Advanced Redox Modulation regimen consisting of melphalan, BCNU, hydroxocobalamin, ascorbic acid, and autologous stem cell infusion in patients with advanced pancreatic or breast cancer. Patients enrolled to date have had an inherited BRCA/PALB2 mutation. For the remainder of the trial, patients with or without an inherited BRCA/PALB2 mutation will be able to enroll.

About General Oncology, Inc.
General Oncology is a clinical-stage biopharmaceutical company dedicated to pioneering first-in-class medicines for metastatic cancers and other proliferative diseases. The Company is developing GO-4, an investigational therapy for metastatic cancers, currently completing the Phase 1 SHARON trial (NCT04150042) for metastatic cancers in the setting of a BRCA1/2 or PALB2 mutation. With a commitment to innovation, General Oncology is focused on advancing transformative therapies for cancer patients. For more information about General Oncology, please visit www.generaloncology.com.

Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995 and applicable securities laws. Forward-looking statements can be identified by words such as “designed to,” “will,” and similar references to future periods. Examples of forward-looking statements include, among others, statements we make regarding the expectations, plans, and prospects generally, and specifically for the SHARON trial, and General Oncology’s drug development programs. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our management’s current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the development and regulatory approval of investigational therapies, patient enrollment, trial execution, safety and efficacy outcomes, and other risks that may be detailed in General Oncology’s filings with the Securities and Exchange Commission. Any forward-looking statements made by us in this press release is based only on information currently available to us and speaks only as of the date on which it is made. General Oncology undertakes no obligation to update or revise any forward-looking statements, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.

Investor Contact:
Abid Ansari
(617) 468-4646
ir@generaloncology.com

Media Contact:
Madelin Hawtin
mhawtins@lifescicomms.com

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